亚特兰大2025年1月27日 /美通社/ -- Cambium Oncology欣然宣布,其主要候选药物ANT308最近在临床前研究中展现了出色的单药疗效和安全性。 该药物不依赖特定基因突变,且公司未观察到剂量限制性毒性。 除了最近获得240万美元的Fast-Track SBIR NIH资助外,他们还获得了中国台湾OEP Innovations的大量投资。
ANT308是一种首创的免疫治疗药物,具有广泛的治疗潜力,可用于血液系统恶性肿瘤和实体瘤,有望提高对其他治疗产生抗药性的癌症的缓解率。 我们的知识产权组合覆盖范围广泛且基础稳固。 我们没有任何债务。
多项概念验证:白血病和胰腺癌
(1)白血病
ANT308在2种小鼠模型中展现出强大的单药抗白血病活性。
(2)胰腺癌
ANT308在3种胰腺癌模型中展现出与抗PD-1检查点抑制剂的协同作用。
ANT308是一种专有的小分子拮抗剂,可阻断人T细胞上的VIP受体信号传导,从而克服肿瘤微环境中的免疫抑制。
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